Here I present: “Bronchial Hyperresponsiveness (Asthma)“, Victor McKusick, Mendelian Inheritance in Man’, 1966. 支氣管哮喘。(BHR).
INTRODUCTION.
Asthma is associated with traits that include clinical symptoms of asthma, such as coughing, wheezing, and dyspnea; bronchial hyperresponsiveness (BHR) as assessed by methacholine challenge test; serum IgE levels; atopy; and atopic dermatitis
Bronchial Hyperresponsiveness-Asthma (BHR) is associated with two (2) different genes on chromosome-five (#5) at cytogenetic locations 5q31.1 and 5q32. The screenshots of the IL13 5:132,656,522-132,661,110 & SCGB3A2 5:147,878,711-147,882,191 genes 4,589 bp (base pairs) & 3,481 bp (base pairs) of DNA sequence length is shown BELOW. Nine (9) other genes besides IL13 & SCGB3A2 in the 5q31.1 and 5q32 cytogenetic locations are listed BENEATH.
| Coordinate | Symbol | Genomic Name |
| 5:132,369,710 | SLC22A5 | Solute carrier, family 22 member 5 |
| 5:132,481,609 | IRF1 | Interferon regulatory factor-1 |
| 5:132,541,445 | IL5 | Interleukin-5 |
| 5:132,556,977 | RAD50 | RAD50 double strand break repair |
| 5:132,656,522 | IL13 | Interleukin-13 |
| 5:132,673,989 | IL4 | Interleukin-4 |
| 5:132,688,812 | KIF3A | Kinesin family member 3A |
| 5:132,747,426 | CCNI2 | Cyclin I family, member 2 |
| 5:132,750,819 | SEPT8 | Septin 8 |
| 5:132,822,141 | SHROOM1 | SHROOM family member 1 |
| 5:146,580,742 | PPP2R2B | Protein phosphatase 2, regulatory subunit B |
| 5:147,390,808 | DPYSL3 | Dihydropyrimidinase-like 3 |
| 5:147,585,438 | JAKMIP2 | Janus kinase microtubule-interacting protein 2 |
| 5:147,824,582 | SPINK1 | Serine protease inhibitor, Kazal type I |
| 5:147,878,711 | SCGB3A2 | Secretoglobin, family 3A, member 2 |
| 5:148,063,980 | SPINK5 | Serine protease inhibitor, Kazal type, 5 |
| 5:148,202,778 | SPINK6 | Serine peptidase inhibitor, KAZAL-type, 6 |
| 5:148,268,794 | SPINK13 | Serine protease inhibitor, Kazal-type, 13 |
| 5:148,312,423 | SPINK7 | Serine peptidase inhibitor, Kazal-type, 7 |
| 5:148,321,305 | SPINK9 | Serine protease inhibitor, Kazal-type, 9 |
