Here I present: “Melanoma Growth-Stimulating Activity”, Victor McKusick, Mendelian Inheritance in Man’, 1966. (MGSA).
INTRODUCTION.
Melanoma growth stimulatory activity (MGSA) is an acid and heat stable, auto-stimulatory growth factor which was first isolated from culture medium conditioned by the Hs294T-human melanoma cell line.
Chemokine (CXC motif) ligand-1 (CXCL1) is a small peptide belonging to the CXC-chemokine family that acts as a chemoattractant for several immune cells, especially neutrophils or other non-hematopoietic cells to the site of injury or infection and plays an important role in regulation of immune and inflammatory responses.
CXCL1 was previously called melanoma growth stimulating activity (MGSA).
The is evidence CXCL1 is encoded on cytogenetic location 4q13.3 and genomic coordinates 4:73,869,393-73,871,308. The screenshot of the CXCL1 gene 1,916 bp (base pairs) of DNA sequence length is shown BELOW. Nine (9) other genes besides CXCL1 in the 4q13.3 are listed BENEATH.
| Coordinate | Symbol | Genomic Name |
| 4:73,848,736 | PPBPP1 | Pro-platelet basic protein pseudogene 1 |
| 4:73,853,296 | PF4V1 | Platelet factor 4, variant 1 (PF4-like) |
| 4:73,869,393 | CXCL1 | Chemokine, C-X-C, ligand 1 (melanoma growth stimulating activity) |
| 4:73,980,811 | PF4 | Platelet factor 4 |
| 4:73,986,439 | PPBP | Pro-platelet basic protein |
| 4:73,995,642 | CXCL5 | Chemokine, C-X-C motif, ligand 5 |
| 4:74,036,589 | CXCL3 | Chemokine, C-X-C motif, ligand 3 (GRO3 oncogene) |
| 4:74,054,038 | PPBPP2 | Pro-platelet basic protein pseudogene 2 |
| 4:74,097,040 | CXCL2 | Chemokine, C-X-C motif, ligand 2 (GRO2 oncogene) |
| 4:74,114,560 | MTHFD2L | Methylenetetrahydrofolate dehydrogenase 2-like, NADP(+)-dependent |
