Here I present: “Psoriasis Susceptibility”, Victor McKusick, Mendelian Inheritance in Man’, 1966. 银屑病易感性。
INTRODUCTION.
Psoriasis is a long-lasting, noncontagious autoimmune disease characterized by patches of abnormal skin. These areas are red, pink, or purple, dry, itchy, and scaly. Psoriasis varies in severity from small, localized patches to complete body coverage. Injury to the skin can trigger psoriatic skin changes at that spot, which is known as the Koebner phenomenon.
There is evidence that susceptibility to psoriasis type-5 is conferred by variation in the PSORS5 gene on cytogenetic location 3q21 and genomic coordinates 3:122,200,001-129,500,000. The screenshot of the PSORS5 gene 7,300,000 bp (base pairs) of DNA sequence length is shown BELOW. Nine (9) other genes besides PSOR5 in the 3q21 cytogenetic location are listed BENEATH.
| Coordinate | Symbol | Genomic Name |
| 3:122,200,001 | ERVK-4 | Endogenous retrovirus K, member 4 |
| 3:122,200,001 | FGQTL6 | Fasting plasma glucose level QTL 6 |
| 3:122,200,001 | GLC1C | Glaucoma 1, open angle, C |
| 3:122,200,001 | HCFP1 | Facial paresis, hereditary congenital, 1 |
| 3:122,200,001 | PSORS5 | Psoriasis susceptibility 5 |
| 3:122,325,248 | CSTA | Cystatin A (stefin A) |
| 3:122,359,591 | MIX23 | Mitochondrial matrix import factor 23 |
| 3:122,384,182 | FAM162A | Family with sequence 162, member A |
| 3:122,421,902 | KPNA1 | Karyopherin, alpha-1 |
| 3:122,527,924 | PARP9 |
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