Here I present: “Hyperoxaluria”, Victor McKusick, Mendelian Inheritance in Man’, 1966. 高氧尿症。
INTRODUCTION.
Hyperoxaluria is an excessive urinary excretion of oxalate. Individuals with hyperoxaluria often have calcium oxalate kidney stones (shown ABOVE). There is evidence that hyperoxaluria is caused by a mutation in the Alanine–glyoxylate aminotransferase (Enzyme Commission number EC# 2.6.1.44) AGXT gene on cytogenetic location 2q37.3 and genomic coordinates 2:240,868,824-240,880,500 . The screenshot was the AGXT gene 11,677 bp (base pairs) of DNA sequence length is shown BELOW. Nine (9) other genes besides AGXT in the 2q37.3 cytogenetic location are listed BENEATH.
| Coordinate | Symbol | Genomic Name. |
| 2:240,586,734 | CAPN10 | Calpain-10 |
| 2:240,605,430 | GPR35 | G protein-coupled receptor-35 |
| 2:240,691,866 | AQP12A | Aquaporin 12A |
| 2:240,713,767 | KIF1A | Kinesin family member 1A |
| 2:240,868,824 | AGXT | Alanine–glyoxylate aminotransferase, liver-specific peroxisomal |
| 2:240,997,650 | SNED1 | SUSHI, NIDOGEN, and EGF-like domains protein 1 |
| 2:241,042,586 | MTERF4 | Mitochondrial transcription termination factor 4 |
| 2:241,106,099 | PASK | Pas domain-containing serine-threonine kinase |
| 2:241,149,573 | PPP1R7 | Protein phosphatase 1, regulatory subunit 7 |
| 2:241,188,677 | TMEM16G | Transmembrane protein 16G |
