Here I present: “MALT Lymphoma”, Victor McKusick, Mendelian Inheritance in Man’, 1966.
INTRODUCTION.
MALT lymphoma is a form of lymphoma involving the mucosa-associated lymphoid tissue (MALT), frequently of the stomach, but virtually any mucosal site can be affected. It is a cancer originating from B cells in the marginal zone of the MALT.
There is evidence that MALT lymphoma is associated with somatic mutation in the B-cell leukemia/lymphoma 10 (BCL10) gene on cytogenetic location 1p22.3 and genomic coordinates 1:85,265,776-85,276,632. The screenshot of the BCL10 gene 10,857 bp (base pairs) of DNA sequence length is shown BELOW. Nine (9) other genes besides BCL10 in the 1p22.3 cytogenetic location are listed BENEATH.
| Coordinate | Symbol | Genomic Name. |
| 1:84,925,583 | MCOLN2 | Mucolipin 2 |
| 1:85,018,082 | MCOLN3 | Mucolipin 3 |
| 1:85,062,327 | WDR63 | WD repeat-containing protein 63 |
| 1:85,152,491 | SYDE2 | Synapse defective Rho GTPase homolog 2 |
| 1:85,265,776 | BCL10 | B-cell leukemia/lymphoma 10 |
| 1:85,318,485 | DDAH1 | Dimethylarginine dimethylaminohydrolase-1 |
| 1:85,580,761 | CCN1 | Cellular communication network factor 1 |
| 1:85,649,417 | ZNHIT6 | Zinc finger HIT domain-containing protein 6 |
| 1:85,729,233 | COL24A1 | Collagen, type XXIV, alpha-1 |
| 1:86,346,837 | ODF2L | Outer dense fiber of sperm tails 2-like protein |
