Here I present: “Glaucoma”, Victor McKusick, Mendelian Inheritance in Man’, 1966.
INTRODUCTION.
Glaucoma is a group of eye diseases that lead to damage of the optic nerve, which transmits visual information from the eye to the brain. Glaucoma may cause vision loss if left untreated. It has been called the “silent thief of sight” because the loss of vision usually occurs slowly over a long period of time. A major risk factor for glaucoma is increased pressure within the eye, known as intraocular pressure (IOP). It is associated with old age, a family history of glaucoma, and certain medical conditions or medications.
There is evidence that one form of primary open angle glaucoma (POAG), designated GLC1A, is caused by heterozygous mutation in the MYOC gene on cytogenetic location 1q24.3 and genomic coordinates 1:171,635,417-171,652,688 . The screenshot of the MYOC gene 17,272 bp (base pairs) of DNA sequence length is shown BELOW. Nine (9) other genes besides MYOC in the 1q24.3 cytogenetic location are shown BENEATH.
| Coordinate | Symbol | Genomic Name. |
| 1:171,185,208 | FMO2 | Flavin-containing monooxygenase 2, pulmonary |
| 1:171,248,494 | FMO1 | Flavin-containing monooxygenase 1, fetal liver |
| 1:171,314,183 | FMO4 | Flavin-containing monooxygenase 2, adult liver |
| 1:171,485,530 | PRRC2C | Proline-rich coiled-coil protein 3C |
| 1:171,635,417 | MYOC | Myocilin |
| 1:171,700,160 | VAMP24 | Vesicle-associated membrane protein 4 |
| 1:171,781,660 | EEF1AKNMT | EEF1A lysine and N-terminal methyltransferase |
| 1:171,841,498 | DNM3 | Dynamin 3 |
| 1:172,138,798 | MIR214 | Micro RNA 214 |
| 1:172,138,808 | MIR3120 | Micro RNA 3120 |
