“Autosomal Deafness (dominant & recessive)”, Victor McKusick, Mendelian Inheritance in Man, 1966.

ABOVE is the twenty-four (24) hour day of  CHROMOSOMIC CLOCK and this time is one (#1).

Here I present: “Autosomal Deafness (dominant & recessive)”, Victor McKusick, Mendelian Inheritance in Man’, 1966.  ABOVE is the American Sign Language (ASL) alphabet.

INTRODUCTION.

Recessive inheritance is responsible for about 78% of deafness, while dominant genes causes 20% of deafness; and, less than 2% of deafness is caused by mitochondrial/X-linked genes.

There is evidence that autosomal dominant deafness-37 (DFNA37) is caused by heterozygous mutation in the Collagen type-XI alpha-1 (COL11A1) gene on cytogenetic location 1p21.1  and genomic coordinates 1:102,876,473-103,108,522 . The screenshot of the COL11A1 gene 232,050 bp (base pairs) of DNA sequence length is shown BELOW.