Here I present: “Carney Myxoma-Endocrine Complex”, Victor McKusick, Mendelian Inheritance in Man’, 1966. 卡尼综合体。(CNC2).
INTRODUCTION.
A myxoma is a myxoid tumor of primitive connective tissue. It is most commonly found in the heart (and is the most common primary tumor of the heart in adults) but can also occur in other locations. Carney Myxoma-Endocrine Complex (CNC2) is an autosomal dominant conditions comprising myxomas of the heart and skin, hyperpigmentation of the skin (lentiginosis), and endocrine overactivity. Approximately 7% of all cardiac myxomas are associated with Carney complex (CNC2).
There is evidence that Carney Myxoma-Endocrine Complex (type-2) is caused by a mutation of the CNC2 gene on cytogenetic location 2p16 and genomic coordinates 2:47,500,001-61,000,000 . The screenshot of the CNC2 gene 13,500,000 bp (base pairs) of DNA sequence length is shown BELOW. Nine (9) other genes besides CNC2 in the 2p16 cytogenetic location are listed BENEATH.
| Coordinate | Symbol | Genomic Name. |
| 2:47,335,315 | BCYRN1 | Brain cytoplasmic RNA 1 |
| 2:47,369,311 | EPCAM | Epithelial cellular adhesion molecule |
| 2:47,403,067 | MSH2 | mutS homolog 2 |
| 2:47,500,001 | ASRT3 | Asthma-related traits, susceptibility to, 3 |
| 2:47,500,001 | CNC2 | Carney complex, type II |
| 2:47,500,001 | DYX3 | Dyslexia, susceptibility to, 3 |
| 2:47,500,001 | STQTL24 | Stature quantitative trait locus 24 |
| 2:47,509,290 | KCNK12 | Potassium channel, subfamily K, member 12 |
| 2:47,783,145 | MSH6 | mutS homolog 6 |
| 2:47,806,920 | FBXO11 | F-box only protein 11 |
