Here I present: “T-cell Leukemia Virus Enhancer”, Victor McKusick, Mendelian Inheritance in Man’, 1966. T细胞白血病病毒增强剂。
INTRODUCTION.
Adult T-cell leukemia (ATL) is a cancer of the immune system’s T-cells caused by human T cell leukemia virus type-1 (HTLV-1).
FOXN2 belongs to class 2 of the forkhead box (FOX) family of transcription factors, members of which lack a basic region at the C-terminal end of the FOX domain. There is evidence that HTLV-1 involves a mutation in the Forkhead box N2 (FOXN2) gene on cytogenetic location 2p16.3 and genomic coordinates 2:48,313,659-48,379,295 . The screenshot of the (FOXN2) gene 65,637 bp (base pairs) of DNA sequence length is shown BELOW. Nine (9) other genes besides in the 2p16.3 cytogenetic location are listed BENEATH.
| Coordinate | Symbol | Genomic Name. |
| 2:47,500,001 | STQTL24 | Stature quantitative trait locus 24 |
| 2:47,509,290 | KCNK12 | Potassium channel, subfamily K, member 12 |
| 2:47,783,145 | MSH6 | mutS homolog 6 |
| 2:47,806,920 | FBXO11 | F-box only protein 11 |
| 2:48,313,659 | FOXN2 | Forkhead box N2 |
| 2:48,440,766 | PPP1R21 | Protein phosphatase 1, regulatory subunit 21 |
| 2:48,530,154 | STON1 | Stonin 1 |
| 2:48,617,856 | GTF2A1L | General transcription factor IIA, 1-like |
| 2:48,686,774 | LHCGR | Lutein hormone/choriogonadotropin receptor |
| 2:48,962,157 | FSHR | Follicle stimulating hormone receptor |
