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“Hemolytic-Uremic Syndrome”, Victor McKusick, Mendelian Inheritance in Man, 1966.

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Here I present: “Hemolytic-Uremic Syndrome”, Victor McKusick, Mendelian Inheritance in Man’, 1966.

INTRODUCTION.

Hemolytic–Uremic Syndrome (HUS) is a group of blood disorders characterized by low red blood cells, acute kidney injury, and low platelets.  Initial symptoms typically include bloody diarrhea, fever, vomiting, and weakness.

The development of hemolytic uremic syndrome can be conferred by variation in the gene encoding complement factor H (CFH) on cytogenetic location 1q31.3 and genomic coordinates 1:196,652,043-196,747,504  . The screenshot of the (CFH) gene 95,462 bp (base pairs) of DNA sequence length is shown BELOW. Nine (9) other genes besides (CFH) in cytogenetic location 1q31.3 are listed BENEATH.

 

Coordinate  Symbol  Genomic Name.
1:193,096,465  GLRX2 Glutaredoxin 2
1:193,122,031  CDC73 Cell division cycle 73
1:193,178,730  B3GALT2 UDP-galactose:β-N-acetylglucosamine β-1,3-galactosyltransferase 2
1:196,225,779  KCNT2 Potassium channel, subfamily T, member 2
1:196,652,043  CFH Complement factor H
1:196,774,840  CFHR3 Complement factor H-related 3
1:196,819,731  CFHR1 Complement factor H-related 1
1:196,888,052  CFHR4 Complement factor H-related 4
1:196,943,738  CFHR2 Complement factor H-related 2
1:196,975,034  CFHR5 Complement factor H-related 5

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