“Keutel Syndrome”, Victor McKusick, Mendelian Inheritance in Man, 1966. (MGP)

IDC10–Code = Q87.89

Genomic coordinate (human 12:14,880,864 MGP).

Cytoband (human 12p12.3 MGP).

Intraband %= 5.4% MGP

OMIM’ genes @ 12p12.3 = 20 genes.

Polymorphs = 173 MGP variants in ClinVar.

Hyperbolic Umbilic Chromosome-12 is 1,200 genes.

Here I present: “Keutel Syndrome”, Victor McKusick, Mendelian Inheritance in Man’, 1966. (MGP)

INTRODUCTION.

Matrix Gla protein (MGP) is member of a family of vitamin-K₂ dependent, Gla-containing proteins. MGP has a high affinity binding to calcium ions, similar to other Gla-containing proteins. The protein acts as an inhibitor of vascular mineralization-and plays a role in bone organization.

Abnormalities in the MGP gene have been linked with Keutel syndrome, a condition characterized by abnormal calcium deposition in cartilage, peripheral stenosis of the pulmonary artery, and midfacial hypoplasia.