Genomic coordinate 8:133,237,175
Here I present: “Hereditary Motor-sensory Neuropathy LOM-type”, Victor McKusick, Mendelian Inheritance in Man’, 1966. (HMSNL) 遺傳性運動和感覺神經病變。icd10=G60.0
INTRODUCTION.
Hereditary motor-sensory neuropathy (HMSN) is a name sometimes given to a group of different neuropathies which are all characterized by their impact upon both afferent and efferent neural communication. HMSN are characterised by atypical neural development & degradation of neural tissue.
The two (2) common forms of HMSN are either hypertrophic demyelinated nerves or complete atrophy of neural tissue. Hypertrophic condition causes neural stiffness and a demyelination of nerves in the peripheral nervous system, and complete atrophy causes the breakdown of axons and neural cell bodies.
Hereditary motor-sensory neuropathy LOM-type (HMSNL) Charcot-Marie-Tooth is known to be caused by homozygous mutation in the NDRG1 gene on cytogenetic location 8q24.22 and genomic coordinates 8:133,237,175-133,297,252. The screenshot of the N-myc downstream-regulated gene-1 (NDRG1) gene 60,078 bp (base pairs) of DNA sequence length is shown BELOW. Nine (9) other genes besides NDGR1 in the 8q24.22 cytogenetic location are listed BENEATH.
| Coordinate | Symbol | Genomic Name |
| 8:132,866,958 | TG | Thyroglobulin |
| 8:133,036,728 | SLA | Src-like-adaptor |
| 8:133,054,959 | PTCSC1 | Papillary thyroid carcinoma susceptibility candidate 1 |
| 8:133,191,039 | CCN4 | Cellular communication netowrk factor 4 |
| 8:133,237,175 | NDRG1 | N-myc downstream-regulated gene 1 |
| 8:133,454,848 | ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 |
| 8:134,477,788 | ZFAT1 | Zinc finger gene in autoimmune thyroid disease 1 |
| 8:134,800,520 | MIR30B | Micro RNA 30B |
| 8:134,804,876 | MIR30D | Micro RNA 30D |
| 8:135,457,456 | KHDRBS3 | KH domain-containing, RNA-binding, signal protein 3 |
