Genomic coordinate 7:116,672,196
Here I present: “Papillary Renal-cell Carcinoma”, Victor McKusick, Mendelian Inheritance in Man’, 1966. (PRCC) 乳頭狀腎細胞癌。icd10=C64.9
INTRODUCTION.
Papillary renal-cell carcinoma (PRCC) is a malignant, heterogeneous tumor originating from renal tubular epithelial cells of the kidney, which comprises approximately 15% of all kidney neoplasms.
Based on its morphological features, papillary renal-cell carcinoma (PRCC ) can be classified into two (2) main subtypes, which are type-1 (basophilic) and type-2 (eosinophilic).
Receptor tyrosine kinases (RTK) are high-affinity cell-surface receptors for many polypeptide growth factors, cytokines, and hormones. Of the 90 unique tyrosine kinase identified in the human genome 58 encode receptor tyrosine kinase (RTK) proteins. Receptor tyrosine kinases (RTK) have been shown not only to be key regulators of normal cellular processes, but also to have a critical role in the development and progression of cancers.
MET is a receptor tyrosine kinase (RTK) whose biologic effects are triggered by stimulation of its only ligand, hepatocyte growth factor.
There is evidence that papillary renal-cell carcinoma can be caused by mutation in receptor tyrosine kinase (RTK) protein gene MET encoded on cytogenetic location 7q31.2 and genomic coordinates 7:116,672,196-116,798,377. The screenshot of the MET gene 126,182 bp (base pairs) of DNA sequence length is shown BELOW. Nine (9) other genes besides MET in the 7q31.2 cytogenetic location are listed BENEATH.
| Coordinate | Symbol | Genomic Name |
| 7:115,935,152 | TFEC | Transcription factor EC |
| 7:116,210,539 | TES | Testin |
| 7:116,499,738 | CAV2 | Caveolin-2 |
| 7:116,525,009 | CAV1 | Caveolin-1 |
| 7:116,672,196 | MET | MET protooncogene, receptor tyrosine kinase |
| 7:116,862,587 | CAPZA2 | Capping protein (actin filament) muscle Z-line, alpha 2 |
| 7:116,953,501 | ST7 | Suppressor of tumorigenicity 7 (breast) |
| 7:117,275,451 | WNT2 | Wingless-type MMTV integration site family, member 2 |
| 7:117,363,222 | ASZ1 | Ankyrin repeat, SAM basic leucine zipper domain 1 |
| 7:117,480,025 | CFTR | Cystic fibrosis transmembrane conductance regulator |
