Genomic coordinate 7: 142,749,472
Here I present: “Hereditary Pancreatitis”, Victor McKusick, Mendelian Inheritance in Man’, 1966. 胰臟炎。icd10=K85.90
INTRODUCTION.
Human pancreatic juice contains three (3) isoforms of trypsinogen. On the basis of their relative electrophoretic mobility, these are commonly referred to as cationic trypsinogen (PRSS1), anionic trypsinogen (PRSS2), and mesotrypsinogen (PRSS3). Normally, cationic trypsinogen represents approximately two-thirds of total trypsinogen, while anionic trypsinogen makes up approximately one-third. Mesotrypsinogen is a minor species, accounting for less than 5% of trypsinogens or 0.5% of pancreatic juice proteins.
There is evidence that hereditary pancreatitis can be caused by mutation in the cationic trypsinogen (PRSS1) gene encoded on cytogenetic location 7q34 and genomic coordinates 7:142,749,472-142,753,072. The screenshot of the PRSS1 gene 3,601 bp (base pairs) of DNA sequence length is shown BELOW. Nine (9) other genes besides PRSS1 in the 7q34 cytogenetic location are listed BENEATH.
| Coordinate | Symbol | Genomic Name |
| 7:141,790,217 | TAS2R5 | Taste receptor type 2, member 5 |
| 7:141,927,357 | CLEC5A | C-type lectin domain family 5, member A |
| 7:141,972,631 | TAS2R38 | Taste receptor, type 2, member 38 |
| 7:141,986,518 | MGAM | Maltase-glucoamylase |
| 7:142,749,472 | PRSS1 | Protease, serine, 1 (trypsin 1) |
| 7:142,770,970 | PRSS2 | Protease, serine, 2 (trypsin 2) |
| 7:142,786,213 | TRBD1 | T-cell receptor beta chain diversity gene 1 |
| 7:142,791,694 | TRBC1 | T-cell receptor beta chain constant region 1 |
| 7:142,795,705 | TRBD2 | T-cell receptor beta chain diversity gene 2 |
| 7:142,801,041 | TRBC2 | T-cell receptor beta chain constant region 2 |
