
Genomic coordinate 7:60,100,001.
Here I present: “Hyperreflexia”, Victor McKusick, Mendelian Inheritance in Man’, 1966. (HRX) 反射亢進。icd10=R29.2 ·
INTRODUCTION.
Hyperreflexia (HRX) is overactive or overresponsive bodily reflexes. Examples of this include twitching and spastic tendencies, which indicate disease of the upper motor neurons and the lessening or loss of control ordinarily exerted by higher brain centers of lower neural pathways.
There is evidence that hyperreflexia is caused by mutation in the HXR gene on cytogenetic location 7q and genomic coordinates 7:60,100,001-159,345,973. The screenshot of the HXR gene 99,245,973 bp (base pairs) of DNA sequence length is shown BELOW. Eight (8) other genes besides HXR around the 7q11.1 cytogenetic location are listed BENEATH.
| Coordinate | Symbol | Genomic Name |
| 7:56,064,286 | SUMF2 | Sulfatase-modifying factor 2 |
| 7:56,080,295 | PHKG1 | Phosphorylase kinase, gamma 1, muscle |
| 7:56,101,573 | CHCHD2 | Coiled-coil-helix-coiled-coil-helix protein-2 |
| 7:60,100,001 | HRX | Hyperreflexia |
| 7:62,100,001 | ANIB1 | Aneurysm, intracranial berry, 1 |
| 7:62,100,001 | EEC1 | Ectrodactyly, ectodermal dysplasia, cleft lip/palate, 1 |
| 7:62,100,001 | EOE1 | Esophagitis, eosinophilic, 1 |
| 7:64,666,133 | ZNF107 | Zinc finger protein-107 |
| 7:64,794,428 | ZNF138 | Zinc finger protein-138 |

