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“Hyperreflexia”, Victor McKusick, Mendelian Inheritance in Man, 1966. (HRX) 反射亢進。icd10=R29.2

Genomic coordinate 7:60,100,001.


Here I present: “Hyperreflexia”, Victor McKusick, Mendelian Inheritance in Man’, 1966. (HRX) 反射亢進。icd10=R29.2 · 

INTRODUCTION.

Hyperreflexia (HRX) is overactive or overresponsive bodily reflexes. Examples of this include twitching and spastic tendencies, which indicate disease of the upper motor neurons and the lessening or loss of control ordinarily exerted by higher brain centers of lower neural pathways.  

There is evidence that hyperreflexia is caused by mutation in the HXR gene on cytogenetic location 7q and genomic coordinates 7:60,100,001-159,345,973. The screenshot of the HXR gene 99,245,973 bp (base pairs) of DNA sequence length is shown BELOW. Eight (8) other genes besides HXR around the 7q11.1 cytogenetic location are listed BENEATH.





 

 

Coordinate  Symbol  Genomic Name
7:56,064,286  SUMF2 Sulfatase-modifying factor 2
7:56,080,295  PHKG1 Phosphorylase kinase, gamma 1, muscle
7:56,101,573  CHCHD2 Coiled-coil-helix-coiled-coil-helix protein-2
7:60,100,001  HRX Hyperreflexia
7:62,100,001  ANIB1 Aneurysm, intracranial berry, 1
7:62,100,001  EEC1 Ectrodactyly, ectodermal dysplasia, cleft lip/palate, 1
7:62,100,001  EOE1 Esophagitis, eosinophilic, 1
7:64,666,133  ZNF107 Zinc finger protein-107
7:64,794,428  ZNF138 Zinc finger protein-138

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