Here I present: “Open-angle Glaucoma”, Victor McKusick, Mendelian Inheritance in Man’, 1966. (ABS10) 開角青光眼。icd10=H40.11
INTRODUCTION.
Open-angle glaucoma is the most common type of glaucoma.
- The cause is unknown. The increase in eye pressure happens slowly over time. You cannot feel it.
- The increased pressure pushes on the optic nerve. Damage to the optic nerve causes blind spots in your vision.
- Open-angle glaucoma tends to run in families. Your risk is higher if you have a parent or grandparent with open-angle glaucoma.
ABOVE is the chromosome assignments of eight (8) open-angle glaucoma genes:
1. MYOC
2. EFEMP1
3. IL20RB
5. WDR36
7. ASB10
10. OPTN
12. TBK1
19. NTF4
There is evidence that open-angle glaucoma type-1F is caused by heterozygous mutation in the ankyrin repeat- and SOCS box-containing protein-10 (ASB10) gene on cytogenetic location 7q36.1 and genomic coordinates 7:151,175,698-151,187,792. The screenshot of the ASB10 gene 12,095 bp (base pairs) of DNA sequence length is shown BELOW. Nine (9) other genes besides ASB10 in the 7q36.1 cytogenetic location are listed BENEATH.
| Coordinate | Symbol | Genomic Name |
| 7:151,076,624 | FASTK | Fas-activated serine/threonine kinase |
| 7:151,081,085 | TMUB1 | Transmembrane and ubiquitin-like domain-containing protein 1 |
| 7:151,085,867 | AGAP3 | ARF GTPase-activating protein with GTPase domain, ankyrin repeat, pleckstrin 3 |
| 7:151,148,009 | GBX1 | Gastrulation brain homeobox 1 |
| 7:151,175,698 | ASB10 | Ankyrin repeat- and SOCS box-containing protein 10 |
| 7:151,211,484 | ABCF2 | ATP-binding cassette, subfamily F, member 2 |
| 7:151,232,483 | CHPF2 | Chondroitin polymerizing factor 2 |
| 7:151,238,421 | MIR671 | Micro RNA 671 |
| 7:151,238,780 | SMARCD3 | SWI/SNF related, matrix-associated, actin-dependent regulator of chromatin, D-3 |
| 7:151,341,812 | NUB1 | Negative regulator of ubiquitin-like proteins 1 |
