Here I present: “Pleomorphic Adenoma”, Victor McKusick, Mendelian Inheritance in Man’, 1966. 多型性腺瘤。icd10=D11.0
INTRODUCTION.
Pleomorphic adenoma is a common benign salivary gland neoplasm characterized by neoplastic proliferation of epithelial (ductal) cells along with myoepithelial components, having a malignant potentiality. It is the most common type of salivary gland tumor and the most common tumor of the parotid gland. It derives its name from the architectural pleomorphism (variable appearance) seen by light microscopy. It is also known as “Mixed salivary gland tumor“, which refers to its dual origin from epithelial and myoepithelial elements’ as opposed to its pleomorphic appearance.
There is evidence that pleomorphic adenoma is caused by mutation in the PLAGL1 encoded zinc finger DNA-binding transcription factor that can regulate apoptosis and cell cycle arrest. The PLAG1 gene is encoded on cytogenetic location 6q24.2 and genomic coordinates 6:143,940,300-144,064,599. The screenshot of the PLAG1 gene 124,300 bp (base pairs) of DNA sequence length is shown BELOW. Nine (9) other genes besides PLAG1 in the 6q24.2 cytogenetic location are listed BENEATH.
| Coordinate | Symbol | Genomic Name |
| 6:143,450,805 | PEX3 | Peroxisomal biogenesis factor-3 |
| 6:143,494,812 | FUCA2 | Fucosidase, alpha-L- 2, plasma |
| 6:143,536,878 | PHACTR2 | Phosphatase and actin regulator 2 |
| 6:143,843,338 | LTV1 | LTV1 ribosome biogenesis factor |
| 6:143,940,300 | PLAGL1 | Pleomorphic adenoma gene-like 1 |
| 6:144,004,916 | HYMAI | Hydatidiform mole-associated and imprinted transcript |
| 6:144,094,884 | SF3B5 | Splicing factor 3B, subunit 5 |
| 6:144,139,963 | STX11 | Syntaxin-11 |
| 6:144,285,335 | UTRN | Utrophin (homologous to dystrophin) |
| 6:145,383,353 | EPM2A | EPM2A glucan phosphatase, laforin |
