Here I present: “Human Immunodeficiency Virus Type-1”, Victor McKusick, Mendelian Inheritance in Man’, 1966. (HIV1) 人体免疫缺陷病毒1型。icd10=B20
INTRODUCTION.
The pathogenesis of the Human Immunodeficiency Virus Type-1 (HIV1) infection and the progression from infection to AIDS vary significantly between exposed individuals. Infection occurs after the virus, which has macrophage (M)- and T lymphocyte (T)-tropic strains and more than 12 subtypes,survives an array of nonspecific, nongenetic environmental and host factors.
Variation in several different genes influences susceptibility and resistance to HIV-1 infection and the rate of progression to AIDS after infection including major histocompatibility-complex, class I-C (HLA-C) on cytogenetic location 6p21.33 and genomic coordinates 6:31,268,749-31,272,092. The screenshot of the HLA-C gene 3,344 bp (base pairs) of DNA sequence length is shown BELOW. Nine (9) other genes besides HLA-C on cytogenetic location 6p21.33 are listed BENEATH.
| Coordinate | Symbol | Genomic Name |
| 6:31,142,439 | CCHCR1 | Coiled-coil alpha-helical rod protein 1 |
| 6:31,158,589 | TCF19 | Transcription factor-19 (SC1) |
| 6:31,164,337 | POU5F1 | Pou domain, class 5, transcription factor 1 |
| 6:31,173,735 | PSORS1C3 | Psoriasis susceptibility 1 candidate 3, noncoding |
| 6:31,268,749 | HLA-C | Major histocompatibility complex, class I, C |
| 6:31,353,875 | HLA-B | Major histocompatibility complex, class I, B |
| 6:31,400,711 | MICA | MHC class I polypeptide-related sequence A |
| 6:31,463,180 | HCP5 | Major histocompatibility complex, class I, gene P5-1 |
| 6:31,494,918 | MICB | MHC class I polypeptide-related sequence B |
| 6:31,528,962 | MCCD1 | Mitochondrial coiled-coil domain 1 |
