Here I present: “Coagulation Factor XIII”, Victor McKusick, Mendelian Inheritance in Man’, 1966. 凝血因子XII。(F13A1) icd10=D68. 26
INTRODUCTION.
The blood coagulation factor-XIII (F13A1) gene encodes the A subunit of factor XIII (EC 2.3.2.13), the last enzyme generated in the blood coagulation cascade. It is the zymogen for fibrinoligase, a transglutaminase that forms intramolecular gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules and thus stabilizes blood clots. Plasma factor XIII is composed of 2 A subunits, which have catalytic function, and 2 noncatalyic B subunits (F13B), which likely act as carrier proteins. However, both platelet and placental factor XIII are composed only of 2 A subunits. All forms of factor XIII are proteolytically activated by thrombin.
There is evidence that the blood coagulation factor-XIII gene (F13A1) is encoded on cytogenetic location 6p25.1 and genomic coordinates 6:6,144,084-6,320,662. The screenshot of the F13A1 gene 176,579 bp (base pairs) of DNA sequence length is shown BELOW. Nine (9) other genes besides F13A1 in cytogenetic location 6p25.1 are listed BENEATH.
| Coordinate | Symbol | Genomic Name |
| 6:5,031,753 | LYRM4 | LYR motif-containing protein 4 |
| 6:5,085,341 | PPP1R3G | Protein phosphatase 1, regulatory subunit 3G |
| 6:5,249,934 | FARS2 | Phenylalanyl-tRNA synthetase 2, mitochondrial |
| 6:5,997,999 | NRN1 | Neuritin 1 |
| 6:6,144,084 | F13A1 | Coagulation factor XIII, A polypeptide |
| 6:6,588,720 | LY86 | Lymphocyte antigen 86 |
| 6:7,100,001 | OFC1 | Orofacial cleft-1 |
| 6:7,107,743 | RREB1 | RAS-responsive element binding protein-1 |
| 6:7,281,143 | SSR1 | Signal sequence receptor, alpha |
| 6:7,326,659 | CTAG3 | Cancer/testis antigen 3 |
