Here I present: “Schistosoma-mansoni Infection”, Victor McKusick, Mendelian Inheritance in Man’, 1966. 血管瘤-曼索尼感染。(SM1) icd10=B65.1
INTRODUCTION.
Schistosoma-mansoni is a water-borne parasite of humans and belongs to the group of blood flukes (Schistosoma). The adult lives in the blood vessels (mesenteric veins) near the human intestine. It causes intestinal schistosomiasis (similar to S. japonicum, S. mekongi, S. guineensis, and S. intercalatum). Clinical symptoms are caused by the eggs. As the leading cause of schistosomiasis in the world, it is the most prevalent parasite in humans. It is classified as a neglected tropical disease. As of 2021, the World Health Organization reports that 251.4 million people have schistosomiasis and most of it is due to Schistosoma-mansoni.
There is evidence that the susceptibility to Schistosoma-mansoni infection (SM1) is caused by mutation in the (SM1) gene on cytogenetic location 5q31-q33 and genomic coordinates 5:131,200,001-160,500,000. The screenshot of the SM1 gene 29,300,000 bp (base pairs) of DNA sequence length is shown BELOW. Nine (9) other genes besides SM1 in the 5q31-q33 cytogenetic location are listed BENEATH.
| Coordinate | Symbol | Genomic Name |
| 5:131,200,001 | PDB4 | Paget disease of bone 4 |
| 5:131,200,001 | PFBI | Plasmodium falciparum blood infection levels |
| 5:131,200,001 | PSORS11 | Psoriasis susceptibility 11 |
| 5:131,200,001 | RLS8 | Restless legs syndrome, susceptibility to, 8 |
| 5:131,200,001 | SM1 | Schistosoma mansoni infection |
| 5:131,210,052 | CDC42SE2 | CDC42 small effector 2 |
| 5:131,423,921 | RAPGEF6 | RAP guanine nucleotide exchange factor 6 |
| 5:131,641,714 | FNIP1 | Folliculin-interacting protein 1 |
| 5:131,806,990 | MEIKIN | Meiotic kinetochore factor |
| 5:131,949,973 | ACSL6 | Acyl-CoA synthetase long-chain family member 6 |
