Here I present: “Polycystic Ovary Syndrome”, Victor McKusick, Mendelian Inheritance in Man’, 1966. 卵巢多囊綜合徵。(PCOS).
INTRODUCTION.
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. The name ‘polycystic ovary syndrome (PCOS) is a misnomer as not all women with this condition develop cysts on their ovaries. The name originated from the observation of cysts which form on the ovaries of some women with this condition, though this is not a universal symptom and not the underlying cause of the disorder.
There is evidence that polycystic ovary syndrome type-1 (PCOS1) is caused by mutation in the PCOS1 gene on cytogenetic location 19p13.2 and genomic coordinates 19:6,900,001-12,600,000. The screenshot of the PCOS1 gene 5,700,000 bp (base pairs) of DNA sequence length is shown BELOW. Nine (9) other genes besides PCOS1 in the 19p13.2 cytogenetic location are listed BENEATH.
| Coordinate | Symbol | Genomic Name |
| 19:6,887,579 | ADGRE1 | Adhesion G protein-coupled receptor E1 |
| 19:6,900,001 | LPSA | Oncogene liposarcoma |
| 19:6,900,001 | NRCLP6 | Narcolepsy 6 |
| 19:6,900,001 | PAPA3 | Polydactyly, postaxial, type A3 |
| 19:6,900,001 | PCOS1 | Polycystic ovary syndrome 1 |
| 19:6,900,001 | TCO | Thyroid carcinoma, nonmedullary, with cell oxyphilia |
| 19:6,950,758 | ADGRE4P | Adhesion G protein-coupled receptor E4, pseudogene |
| 19:7,049,321 | MBD3L2 | Methyl-CpG binding domain protein 3-like 2 |
| 19:7,112,265 | INSR | Insulin receptor |
| 19:7,348,937 | ARHGEF18 | Rho guanine nucleotide exchange factor 18 |
