“Acute Promyelocytic Leukemia”, Victor McKusick, Mendelian Inheritance in Man, 1966. 急性原骨髓細胞白血病。(APL).

Here I present: “Acute Promyelocytic Leukemia”, Victor McKusick, Mendelian Inheritance in Man’, 1966. 急性原骨髓細胞白血病。（APL).

INTRODUCTION.

Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia (AML), a cancer of the white blood cells.  In APL, there is an abnormal accumulation of immature granulocytes called promyelocytes. 

Acute promyelocytic leukemia (APL) is associated with 2 cardinal features: a granulocytic differentiation block and reciprocal and balanced translocations that always involve rearrangement of the RARA gene. The most frequent translocation is t(15,17)(q22;q21), which fuses the RARA gene with the PML gene and represents more than 98% of APL.

There is evidence acute promyelocytic leukemia (APL) results from translocations that always involve the gene encoding retinoic acid receptor-alpha polypeptide (RARA) on cytogenetic location 17q21.2 and genomic coordinates 17:40,309,180-40,357,643. The screenshot of the RARA gene 48,464 bp (base pairs) of DNA sequence length is shown BELOW.  Nine (9) other genes besides RARA in the 17q21.2 cytogenetic location are listed BENEATH.

 

 

Coordinate	Symbol	Genomic Name
17:40,140,537	MLN51	MLN51 gene
17:40,200,001	IBD22	Inflammatory bowel disease 22
17:40,219,304	WIRE	WASP-interacting protein-related protein
17:40,287,879	CDC6	Cell division cycle 6
17:40,309,180	RARA	Retinoic acid receptor, alpha polypeptide
17:40,360,652	GJD3	Gap junction protein, delta-3
17:40,388,525	TOP2A	Topoisomerase (DNA) II, alpha
17:40,443,450	IGFBP4	Insulin-like growth factor-binding protein-4
17:40,475,834	TNS4	Tensin 4
17:40,553,769	CCR7	Chemokine (C-C) receptor 7