Here I present: James Watson, “The Double Helix”, 1968. PART TWO (2).
INTRODUCTION.
In 1953 when, James Watson at age 23 and Francis Crick at age 32 discovered the double-helix structure of DNA they presented the greatest scientific publication of later-half of the twentieth (20) century.
I qualify that statement, since Marie Curie (1904) & Albert Einstein (1905) produced the most influential scientific publications in the first-half of the twentieth (20) century.
COMMENTS.
Most of my blog post are of Victor McKusick, Mendelian Inheritance in Man’, 1966. The data of human genome is in the table ABOVE. BELOW is how the “giemsa stain” renders black, gray & white contrast in the microscopy of chromosomal DNA.
The “giemsa stain” renders black (AT), gray (AT:GC) & white (GC) chromosomal DNA visible in microscopy.
As an EXAMPLE, from my blog post on “dilated cardiomyopathy”. The genomic coordinate is 3:52,451,100 in cytogenetic location 3p21.1 . This is the “troponin-C1, slow” (TNNC1) gene that a mutated form gives patients “dilated cardiomyopathy”.
OPINION.
I stated that the genomic coordinate of the TNNC1 gene is base pair 52,451,100 and the table ATOP lists chromosome #3 as 198,295,559 base pairs.
In the 1953 photograph of James Watson & Francis Crick (shown ATOP). You imagine yourself standing beside your own #3 chromosomal DNA if you suffer from “dilated cardiomyopathy”. Inside your body is not science, biological sequence is suffering “dilated cardiomyopathy”.
James Watson & Francis Crick presented the most significant technical publication of the later-half of the twentieth (20) century. James Watson, “The Double Helix”, 1968 is part of the popular culture of today.
| Coordinate | Symbol | Genomic Name. |
| 3:52,310,920 | DNAH1 | Dynein, axonemal, heavy chain-1 |
| 3:52,401,008 | BAP1 | BRCA1 associated protein-1 |
| 3:52,410,660 | PHF7 | PHD finger protein 7 |
| 3:52,433,035 | SEMA3G | Semaphorin 3G |
| 3:52,451,100 | TNNC1 | Troponin-C1, slow |
| 3:52,455,604 | NISCH | Nischarin |
| 3:52,495,338 | STAB1 | Stabilin 1 |
| 3:52,536,605 | UQCC5 | Ubiquinol-cytochrome c reductase 5 |
| 3:52,545,367 | PBRM1 | Polybromo 1 |
| 3:52,685,920 | GNL3 | Guanine nucleotide-binding protein 3 |
