Here I present: “Dyslexia Type-2”, Victor McKusick, Mendelian Inheritance in Man’, 1966. 2型閱讀障礙。icd10=F81.0 (DYX2).
INTRODUCTION.
Dyslexia (DYX) is a disorder manifested by difficulty learning to read despite conventional instruction, adequate intelligence, and sociocultural opportunity. It is the most common neurodevelopmental disorders, with a prevalence of 5 to 12%. Although there is evidence for familial clustering and heritability, the disorder is considered a complex multifactorial trait.
Developmental Cognitive Disability (DCD) and Emotional Behavioral Disability (EBD) are not Specific Learning Disability (SLD) all of which are listed BELOW.
Developmental Cognitive Disability (DCD):
F70 – Mild intellectual disabilities
F71 – Moderate intellectual disabilities
F72 – Severe intellectual disabilities
F73 – Profound intellectual disabilities
F78 – Other intellectual disabilities
F79 – Unspecified intellectual disabilities
Specific Learning Disability (SLD):
F81.0 – Specific reading disorder
F81.1 – Specific spelling disorder
F81.2 – Mathematics disorder
F81.81 – Disorder of written expression
F81.89 – Other developmental disorders of scholastic skills
F81.9 – Developmental disorder of scholastic skills, unspecified
Emotional Behavioral Disability (EBD):
F88 – Other disorders of psychological development
F89 – Unspecified disorder of psychological development
F90.0 – Attention-deficit hyperactivity disorder, predominantly inattentive type
F90.1 – Attention-deficit hyperactivity disorder, predominantly hyperactive type
F90.2 – Attention-deficit hyperactivity disorder, combined type
F90.8 – Attention-deficit hyperactivity disorder, other type
F90.9 – Attention-deficit hyperactivity disorder, unspecified
There is evidence that variation in the dyslexia type-2 gene may be the basis of the form of dyslexia type-2 (DYX2) that maps to cytogenetic location 6p22-p21 and genomic coordinates 6:15,200,001-46,200,000. The screenshot of the DYX2 gene 31,000,000 bp (base pairs) of DNA sequence length is shown BELOW. Nine (9) other genes besides DYX2 in the 6p22-p21 cytogenetic location are listed BENEATH.
| Coordinate | Symbol | Genomic Name |
| 6:15,200,001 | ALPQTL3 | Alkaline phosphatase, plasma level of, QTL 3 |
| 6:15,200,001 | BWQTL4 | Birth weight quantitative trait locus 4 |
| 6:15,200,001 | CIHL | Hearing loss, cisplatin-induced, susceptibility to |
| 6:15,200,001 | CMAHP | Cytidine monophospho-N-acetylneuraminic acid hydroxylase pseudogene |
| 6:15,200,001 | DYX2 | Dyslexia, susceptibility to, 2 |
| 6:15,200,001 | NBLST4 | Neuroblastoma, susceptibility to, 4 |
| 6:15,200,001 | OTSC3 | Otosclerosis 3 |
| 6:15,246,069 | JARID2 | Jumonji and AT-rich interaction domain containing 2 |
| 6:15,522,807 | DTNBP1 | Dystrobrevin-binding protein 1 (dysbindin) |
| 6:16,129,086 | MYLIP | Myosin regulatory light chain-interacting protein |
