Here I present: “Psoriasis Susceptibility”, Victor McKusick, Mendelian Inheritance in Man’, 1966. 銀屑病的易感性。(PSORS3).
INTRODUCTION.
Psoriasis vulgaris (PV) is a chronic inflammatory dermatosis that affects approximately 2% of the population. It is characterized by red, scaly skin patches that are usually found on the scalp, elbows, and knees, and may be associated with severe arthritis. The lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis. The usual age of onset of psoriasis is between 15 and 30 years, although it can present at any age.
Generalized pustular psoriasis (GPP) is a life-threatening disease characterized by sudden, repeated episodes of high-grade fever, generalized rash, and disseminated pustules, with hyperleukocytosis and elevated serum levels of C-reactive protein. GPP often presents in patients with existing or prior psoriasis vulgaris (PV); however, GPP can develop without a history of PV. Palmoplantar pustulosis and acrodermatitis continua of Hallopeau represent acral forms of pustular psoriasis that have historically been grouped with GPP.
There is evidence that susceptibility to psoriasis type-3 is conferred by variation in PSORS3 gene on cytogenetic location 4q and genomic coordinates 4:50,000,001-190,214,555. The screenshot of the PSORS3 gene 140,214,555 bp (base pairs) of DNA sequence length is shown BELOW. Nine (9) other genes besides PSORS3 in the 4q cytogenetic location are listed BENEATH.
| Coordinate | Symbol | Genomic Name |
| 4:48,805,156 | OCIAD1 | OCIA domain-containing protein 1 |
| 4:48,885,019 | OCIAD2 | OCIA domain-containing protein 2 |
| 4:48,986,275 | CWH43 | Cell wall biogenesis protein 43 C-terminal homolog |
| 4:50,000,001 | MHW2 | Mental health wellness 2 |
| 4:50,000,001 | PSORS3 | Psoriasis susceptibility 3 |
| 4:50,000,001 | WM2 | Macroglobulinemia, Waldenstrom, susceptibility to, 2 |
| 4:51,800,001 | DFNB55 | Deafness, autosomal recessive 55 |
| 4:51,800,001 | MRT31 | Intellectual developmental disorder 31 |
| 4:51,800,001 | MYP9 | Myopia 9 |
| 4:51,800,001 | TAPVR1 | Total anomalous pulmonary venous return 1 |
