Here I present: “Myeloid/Lymphoid Mixed-Lineage Leukemia”, Victor McKusick, Mendelian Inheritance in Man’, 1966. 骨髓性/淋巴混合血統白血病。(MLLT2).
INTRODUCTION.
Leukemia is a group of blood cancers that usually begin in the bone marrow and produce high numbers of abnormal blood cells. These blood cells are not fully developed and are called blasts or leukemia cells. Symptoms may include bleeding and bruising, bone pain, fatigue, fever, and an increased risk of infections. These symptoms occur due to a lack of normal blood cells.
There is evidence myeloid/lymphoid mixed-lineage leukemia-2 (MLLT2) is caused by mutation in the ALF transcription elongation factor-1 (AFF1) gene on cytogenetic location 4q21.3-q22.1 and genomic coordinates 4:86,935,011-87,141,039. The screenshot of the AFF1 gene 206,029 bp (base pairs) of DNA sequence length is shown BELOW. Nine (9) other genes besides AFF1 in the 4q21.3-q22.1 cytogenetic location are listed BENEATH.
| Coordinate | Symbol | Genomic Name |
| 4:85,475,150 | ARHGAP24 | RHO GTPase-activating protein 24 |
| 4:86,010,405 | MAPK10 | Mitogen-activated protein kinase 10 |
| 4:86,594,315 | PTPN13 | Protein tyrosine phosphatase, nonreceptor-type, 13 |
| 4:86,823,468 | SLC10A6 | Solute carrier family 10 member 6 |
| 4:86,935,011 | AFF1 | AF4/FMR2 family, member 1 |
| 4:87,100,001 | ATOD8 | Dermatitis, atopic, 8 |
| 4:87,100,001 | MUSQTL1 | Musical aptitude quantitative trait locus 1 |
| 4:87,100,001 | MYP11 | Myopia 11 |
| 4:87,160,103 | KLHL8 | Kelch-like 8 |
| 4:87,303,794 | HSD17B13 | 17-beta-hydroxysteroid dehydrogenase XIII |
