Here I present: “Pilomatrixoma”, Victor McKusick, Mendelian Inheritance in Man’, 1966. 毛瘤。(PTR).
INTRODUCTION.
Pilomatrixoma is a benign skin tumor derived from the hair matrix. These neoplasms are relatively uncommon and typically occur on the scalp, face, and upper extremities. Clinically, pilomatrixomas present as a subcutaneous nodule or cyst with unremarkable overlying epidermis that can range in size from 0.5 to 3.0 cm, but the largest reported case was 24 cm.
There is evidence some cases of pilomatrixoma are caused by somatic mutation in the beta-catenin gene (CTNNB1) on cytogenetic location 3p22.1 and genomic coordinates 3:41,199,505-41,240,443. The screenshot of the CTNNB1 gene 40,939 bp (base pairs) of DNA sequence length is shown BELOW. Nine (9) other genes besides CTNNB1 in the 3p22.1 cytogenetic location are listed BENEATH.
| Coordinate | Symbol | Genomic Name |
| 3:39,467,680 | MOBP | Myelin-associated oligodendrocyte basic protein |
| 3:39,808,914 | MYRIP | Myosin VIIA- and RAB-interacting protein |
| 3:40,387,184 | ENTPD3 | Ectonucleoside triphosphate diphosphohydrolase 3 |
| 3:40,457,339 | RPL14 | Ribosomal protein L14 |
| 3:41,199,505 | CTNNB1 | Catenin beta 1 |
| 3:41,246,599 | ULK4 | Unc51-like kinase 4 |
| 3:42,013,093 | TRAK1 | Trafficking protein, kinesin-binding 1 |
| 3:42,257,826 | CCK | Cholecystokinin |
| 3:42,360,764 | LYZL4 | Lysozyme-like 4 |
| 3:42,489,299 | VIPR1 | Vasoactive intestinal peptide receptor 1 |
