Here I present: “Small Cell Lung Cancer”, Victor McKusick, Mendelian Inheritance in Man’, 1966. 小细胞肺癌。(SCLC1)
INTRODUCTION.
Small-cell carcinoma is a type of highly malignant cancer that most commonly arises within the lung, although it can occasionally arise in other body sites, such as the cervix, prostate, and gastrointestinal tract. Compared to non-small cell carcinoma, small cell carcinoma is more aggressive, with a shorter doubling time, higher growth fraction, and earlier development of metastases.
There is evidence small cell lung cancer type 1 (SCLC1) gene encoded on cytogenetic location 3p23-p21 and genomic coordinates 3:30,800,001-54,400,000. The screenshot of the SCLC1 gene 23,800,000 bp (base pairs) of DNA sequence length is shown BELOW. Nine (9) other genes besides SCLC1 on cytogenetic location 3p23-p21 are listed BENEATH.
| Coordinate | Symbol | Genomic Name |
| 3:28,321,047 | AZI2 | 5-azacytidine-induced protein 2 |
| 3:29,281,071 | RBMS3 | RNA-binding motif protein, single strand 3 |
| 3:30,606,356 | TGFBR2 | Transforming growth factor, beta receptor II |
| 3:30,726,197 | GADL1 | Glutamate decarboxylase-like 1 |
| 3:30,800,001 | SCLC1 | Small-cell cancer of lung |
| 3:31,532,925 | STT3B | STT3B, oligosaccharyltransferase |
| 3:31,660,825 | OSBPL10 | Oxysterol-binding protein-like protein 10 |
| 3:32,000,001 | HHV8S | Human herpesvirus 8, susceptibility to |
| 3:32,106,620 | GPD1L | Glycerol-3-phosphate dehydrogenase 1-like |
| 3:32,238,192 | CMTM8 | CKLF-like marvel transmembrane 8 |
