Here I present: “Hepatoblastoma 3p”, Victor McKusick, Mendelian Inheritance in Man’, 1966. 肝母細胞瘤。(CTNNB1).
INTRODUCTION.
Chromosome #3 has two (2) different genes that have been identified in hepatoblastoma: CTNNB1 on 3p22.1 & PIK3CA on 3q26.32. Hepatoblastoma is a malignant liver cancer occurring in infants and children and composed of tissue resembling fetal liver cells, mature liver cells, or bile duct cells. They usually present with an abdominal mass. The disease is most commonly diagnosed during a child’s first three years of life. Alpha-fetoprotein (AFP) levels are commonly elevated, but when AFP is not elevated at diagnosis the prognosis is poor.
There is evidence hepatoblastoma is caused by a mutation in the Catenin (cadherin-associated protein) CTNNB1 gene on cytogenetic location 3p22.1 and genomic coordinates 3:41,199,505-41,240,443. The screenshot of the CTNNB1 gene 40,939 bp (base pairs) of DNA sequence length is shown BELOW. Nine (9) other genes besides CTNNB1 in the cytogenetic location 3p22.1 are listed BENEATH.
| Coordinate | Symbol | Genomic Name |
| 3:39,467,680 | MOBP | Myelin-associated oligodendrocyte basic protein |
| 3:39,808,914 | MYRIP | Myosin VIIA- and RAB-interacting protein |
| 3:40,387,184 | ENTPD3 | Ectonucleoside triphosphate diphosphohydrolase 3 |
| 3:40,457,339 | RPL14 | Ribosomal protein L14 |
| 3:41,199,505 | CTNNB1 | Catenin (cadherin-associated protein), beta 1 |
| 3:41,246,599 | ULK4 | Unc51-like kinase 4 |
| 3:42,013,093 | TRAK1 | Trafficking protein, kinesin-binding 1 |
| 3:42,257,826 | CCK | Cholecystokinin |
| 3:42,360,764 | LYZL4 | Lysozyme-like 4 |
| 3:42,489,299 | VIPR1 | Vasoactive intestinal peptide receptor 1 |
