Here I present: “Male Precocious Puberty”, Victor McKusick, Mendelian Inheritance in Man’, 1966. 男性早熟。
INTRODUCTION.
Precocious puberty symptoms can include fast growth, pubic or underarm hair growth, acne and adult body odor. Children who are born female have a first menstrual period and start to grow breasts. Children who are born male see the testicles and penis grow larger. They also develop a deeper voice and facial hair.
There is evidence that Male Precocious Puberty can be caused by constitutively activating mutations in the luteinizing hormone receptor gene (LHCGR).
The luteinizing hormone/choriogonadotropin receptor (LHCGR) is a transmembrane receptor found predominantly in the ovary and testis, but also many extragonadal organs such as the uterus and breasts. The receptor interacts with both luteinizing hormone (LH) and chorionic gonadotropins (hCG in humans) and represents a G protein-coupled receptor (GPCR). Its activation is necessary for the hormonal functioning during reproduction.
The screenshot of the LHCGR gene 68,951 bp (base pairs) of DNA sequence length on cytogenetic location 2p16.3 and genomic coordinates 2:48,686,774-48,755,724 is shown BELOW. Nine (9) other genes besides LHCGR in the cytogenetic location are listed BENEATH. 
| Coordinate | Symbol | Genomic Name. |
| 2:48,313,659 | FOXN2 | Forkhead box N2 |
| 2:48,440,766 | PPP1R21 | Protein phosphatase 1, regulatory subunit 21 |
| 2:48,530,154 | STON1 | Stonin 1 |
| 2:48,617,856 | GTF2A1L | General transcription factor IIA, 1-like |
| 2:48,686,774 | LHCGR | Lutein hormone/choriogonadotropin receptor |
| 2:48,962,157 | FSHR | Follicle stimulating hormone receptor |
| 2:49,918,503 | NRXN1 | Neurexin 1 |
| 2:53,669,980 | ASB3 | Ankyrin repeat-containing SOCS box protein 3 |
| 2:53,767,783 | CHAC2 | CHAC cation transport regulator homolog 2 |
| 2:53,787,044 | ERLEC1 | Erlectin (endoplasmic reticulum lectin 1) |
