Here I present: “Juvenile Amyotrophic Lateral Sclerosis”, Victor McKusick, Mendelian Inheritance in Man’, 1966. (ALS) 肌萎缩性侧索硬化症。
INTRODUCTION.
Autosomal recessive mutations in the alsin (ALS2) gene lead to a clinical spectrum of motor dysfunction including juvenile amyotrophic lateral sclerosis (ALS2), primary lateral sclerosis, and hereditary spastic paraplegia. The 184-kDa alsin protein is encoded by the full-length (ALS2) gene.
There is evidence juvenile amyotrophic lateral sclerosis-2 (ALS2) can be caused by homozygous mutation in the gene encoding alsin (ALS2) on cytogenetic location 2q33.1 and genomic coordinates 2:201,700,267-201,780,933 . The screenshot of the alsin (ALS2) gene 80,667 bp (base pairs) of DNA sequence length is shown BELOW. Nine (9) other genes besides ALS2 in the 2q33.1 cytogenetic location are listed BENEATH. 
| Coordinate | Symbol | Genomic Name. |
| 2:201,451,740 | STRADB | STE20-related kinase adaptor beta |
| 2:201,487,421 | C2CD6 | C2 calcium-dependent protein 6 |
| 2:201,620,186 | TMEM237 | Transmembrane protein 237 |
| 2:201,644,874 | MPP4 | Membrane protein, palmitoylated 4 |
| 2:201,700,267 | ALS2 | Alsin Rho guanine nucleotide exchange |
| 2:201,806,429 | CDK15 | Cyclin-dependent kinase 15 |
| 2:202,033,855 | FZD7 | Frizzled class receptor 7 |
| 2:202,206,171 | SUMO1 | Small ubiquitin-like modifier 1 |
| 2:202,265,763 | NOP58 | NOP58 ribonucleoprotein |
| 2:202,376,327 | BMPR2 | Bone morphogenetic receptor, type II |
