Here I present: “Ventricular Tachycardia (polymorphic, stress-induced)”, Victor McKusick, Mendelian Inheritance in Man’, 1966. 心室性心动过速。(VT) 心室頻脈。
INTRODUCTION.
Ventricular tachycardia (VT) is a cardiovascular disorder in which fast heart rate occurs in the ventricles of the heart. Although a few seconds of VT may not result in permanent problems, longer periods are dangerous; and multiple episodes over a short period of time are referred to as an electrical storm. Short periods may occur without symptoms, or present with lightheadedness, palpitations, shortness of breath, chest pain, and decreased level of consciousness. Ventricular tachycardia may lead to coma and persistent vegetative state due to lack of blood and oxygen to the brain.
Ventricular tachycardia may result in ventricular fibrillation (VF) and turn into cardiac arrest. This conversion of the VT into VF is called the degeneration of the VT. It is found initially in about 7% of people in cardiac arrest.
There is evidence that catecholaminergic polymorphic ventricular tachycardia type-1 (CPVT1) is caused by heterozygous mutation in the cardiac ryanodine receptor gene (RYR2) on cytogenetic location 1q43 and genomic coordinates 1:237,042,184-237,833,988 . The screenshot of the RYR2 gene 791,805 bp (base pairs) of DNA sequence length is shown BELOW. Nine (9) other genes besides RYR2 in the 1q43 cytogenetic location are listed BENEATH.
| Coordinate | Symbol | Genomic Name. |
| 1:236,518,214 | LGALS8 | Lectin, galactoside-binding, soluble, 8 |
| 1:236,549,005 | HEATR1 | HEAT repeat-containing protein 1 |
| 1:236,686,499 | ACTN2 | Actinin, alpha-2 |
| 1:236,795,281 | MTR | 5-methyltetrahydrofolate-homocysteine methyltransferase 1 |
| 1:237,042,184 | RYR2 | Ryanodine receptor-2 (cardiac) |
| 1:237,882,404 | ZP4 | Zona pellucida glycoprotein 4 |
| 1:239,386,568 | CHRM3 | Cholinergic receptor, muscarinic, 3 |
| 1:240,091,883 | FMN2 | Formin 2 |
| 1:240,489,573 | GREM2 | Gremlin 2, DAN family BMP antagonist |
| 1:240,774,742 | RGS7 | Regulator of G protein signaling 7 |
