
Here I present: “Pheochromocytoma”, Victor McKusick, Mendelian Inheritance in Man’, 1966.
INTRODUCTION.
Paraganglioma are neuroendocrine neoplasms that develop in various body sites: when this type of tumor is found in the adrenal gland, it is referred to as a Pheochromocytoma (the topic of the blog post). Too much adrenaline hormone released from the adrenal glands.
There is evidence that pheochromocytoma type-4 (PPGL4) is caused by heterozygous mutation in the SDHB gene (enzyme commission number EC# 1.3.5.1 succinate dehydrogenase) on cytogenetic location 1p36.13 and genomic coordinates 1:17,018,722-17,054,032 . Ten (10) genes besides the SDBH gene in the 1p36.13 cytogenetic location are listed BELOW.
| Coordinate | Symbol | Genomic Name. |
| 1:16,872,583 | TRE-TTC3-1 | tRNA glutamic acid (anticodon TTC) 3-1 |
| 1:16,914,085 | CROCC | Ciliary rootlet coiled-coil protein |
| 1:16,974,502 | MFAP2 | Microfibrillar-associated protein-2 |
| 1:16,985,958 | ATP13A2 | ATPase 13A2 |
| 1:17,018,722 | SDHB | Succinate dehydrogenase complex, iron-sulfur unit-B |
| 1:17,066,761 | PADI2 | Peptidylarginine deiminase, type II |
| 1:17,205,128 | PADI1 | Peptidylarginine deiminase, type I |
| 1:17,249,098 | PADI3 | Peptidylarginine deiminase, type III |
| 1:17,308,197 | PADI4 | Peptidylarginine deiminase, type IV |
| 1:17,372,196 | PADI6 | Peptidylarginine deiminase, type VI |

