Here I present: “Lupus Nephritis (susceptibility)”, Victor McKusick, Mendelian Inheritance in Man’, 1966.
INTRODUCTION.
Lupus nephritis is an inflammation of the kidneys caused by systemic lupus erythematosus (SLE), an autoimmune disease. It is a type of glomerulonephritis in which the glomeruli become inflamed. Since it is a result of SLE, this type of glomerulonephritis is said to be secondary, and has a different pattern and outcome from conditions with a primary cause originating in the kidney.
Systemic lupus erythematosus (SLE) is a complex autoimmune disease. There is evidence of protein tyrosine phosphatase nonreceptor type-22 (PTPN22) in Lupus nephritis susceptibility. The PTPN22 gene is on 1p13.2 cytogenetic location and genomic coordinates 1:113,813,811-113,871,759. The screenshot of the PTPN22 gene 57,949 bp (base pairs) of DNA sequence length is shown BELOW. Nine (9) other genes besides PTPN22 in the 1p13.2 cytogenetic location are listed BENEATH.
| Coordinate | Symbol | Genomic Name. |
| 1:113,073,198 | LRIG2 | Leucine-rich repeats- and immunoglobulin-like domains protein 2 |
| 1:113,390,515 | MAGI3 | Membrane-associated guanylate kinase, WW and PDZ domains, 3 |
| 1:113,696,831 | PHTF1 | Putative homeodomain transcription factor 1 |
| 1:113,761,832 | RSBN1 | Round spermatid basic protein 1 |
| 1:113,813,811 | PTPN22 | Protein tyrosine phosphatase, nonreceptor-type 22 |
| 1:113,876,816 | BCL2L15 | BCL2-like 15 |
| 1:113,894,194 | AP4B1 | Adaptor-related protein complex 4, beta-1 subunit |
| 1:113,904,619 | DCLRE1B | DNA cross-link repair protein 1B |
| 1:113,929,324 | HIPK1 | Homeodomain-interacting protein kinase 1 |
| 1:113,979,474 | OLFML3 | Olfactomedin-like 3 |
