
Here I present: “Cardiomyopathy”, Victor McKusick, Mendelian Inheritance in Man’, 1966.
INTRODUCTION.
1. Cardiomyopathy is a group of primary diseases of the heart muscle. Early on there may be few or no symptoms. As the disease worsens, shortness of breath, feeling tired, and swelling of the legs may occur, due to the onset of heart failure. An irregular heartbeat and fainting may occur. Those affected are at an increased risk of sudden cardiac death.
2. There is evidence that familial hypertrophic cardiomyopathy-2 (CMH2) is caused by heterozygous mutation in the cardiac troponin-T2 gene (TNNT2) on cytogenetic location 1q32.1 and genomic coordinates 1:201,359,014-201,377,680 . The screenshot of the cardiac troponin-T2 gene (TNNT2) of the 18,667 bp (base pairs) of DNA sequence length is shown BELOW.
