ABOVE is the twenty-four (24) hour day of CHROMOSOMIC CLOCK and this time is fourteen (#14).
Here I present: “Alzheimer Disease”, Victor McKusick, Mendelian Inheritance in Man’, 1966.
Alzheimer Disease (AD) is a neurodegenerative disease that is the cause of 70% of cases of dementia.
Accumulation of amyloid beta is associated with the onset of Alzheimer Disease. Presenilin-1 is one of the four core proteins in the gamma secretase complex, which is considered to play an important role in generation of amyloid beta (Aβ) from amyloid-beta precursor protein (APP).
Early-onset familial Alzheimer Disease type-3 (AD3) is caused by heterozygous mutation in the Presenilin type-1 gene (PSEN1) on cytogenetic location 14q24.2 and genomic coordinates 14:73,136,417-73,223,691 . The screenshot of 87,275 bp (base pairs) of DNA length of the PSEN1 gene is shown BELOW.
